Are there any antidepressants that don't make you feel like ***? (sensitivity to side effects)

Periactin (cyproheptadine) is an antihistamine. Purely anecdotal, I took prescribed antihistamines (mainly promethazine HCl) for hay fever when I was a kid. Summer was the peak allergy season, it was also the end-of-year exam season. This was the 1960s UK, so I was not being treated for ADHD, although I had been previously diagnosed as "hyperactive". I noted some improvement in my ability to focus when I was taking antihistamines. As I say, purely anecdotal and I would not recommend this to anyone else without proper clinical supervision. There is an interesting paper on the links between allergies and ADHD [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455974/]

I didn't read the link.

But in the first phase, at least 4/6 weeks, those who take psychopharmaceuticals never go alone.


The first stage includes suicidal ideation in some.

These disappear during therapy.

There are doctors: they have to follow the patient and give email and telephone numbers during therapy.

In order to understand immediately if there are any problems.

Evidence and hypotheses.

There is numerically low evidence.

Hypotheses and research are continuous.

If a doctor prescribes: trust the doctor, but always ask him right away to follow you even remotely, now technology allows it and how

§

I've read about Dylan: I'm sorry
§

I also note that a precise alert is strictly recommended for patients under 25 and over 65.

The over 65 study is Norwegian I think, but there are others.


§

But here's on the suicidal effects(Adverse effects)

In Italy it has been appearing in information for many years now.

And also the age over 25 years.


Pharmaceutical companies wrote it clearly.


Be very careful because before feeling good, you go through a period of adjustment.

And that needs to be monitored very carefully.

Y

You know, I used to think like you.

I don't know if it also appears in the UK leaflets.

But some things just don't seem to go away with time at all.
A doctor friend of mine has many patients with PSSD.

I wrote about it in 2010 and then there was no single literature.

And I was wrong to averse those who did not know about PSSD effects with just one intake of SSRIs.

To me it was unbelievable.


I was wrong.

§
My doctor friend has adverse effects of PSSD himself

§

They didn't create these discomforts for me, but others, gastric bleeding.

§That said, drugs can be useful.

Sometimes they seem to be, especially in statistics for women.

You wouldn't think so given the hormonal complexity:
Instead I have a lot of excellent feedback on this.
§
In my case the doctor often interrupted even suddenly, I was fine.

The fundamental thing is that they are managed by specialist doctors.

However, I was always better off when I didn't take anything.

Except for an anxiolytic after 8 years of trying a lot of drugs that were previously useless.

§

I'm not a doctor, I just studied Medicine but then I didn't continue (Passion was over for me).

My doctor friend has adverse effects of PSSD himself: § They didn't create these discomforts for me, but others, gastric bleeding. § Having said that, drugs can be useful. Sometimes they seem to be, especially in statistics for women. You wouldn't think so given the hormonal complexity: Instead I have a lot of excellent feedback on this. § In my case the doctor often interrupted even suddenly, I was fine. The fundamental thing is that they are managed by specialist doctors. However, I was always better off when I didn't take anything. Except for an anxiolytic after 8 years of trying a lot of drugs that were previously useless.

Exactly! And how many more! 

How many are treated for ‘whatever ‘ the doctor thinks, with antidepressants? How many missed a diagnosis for autism and handed a prescription for antidepressants! 

Im not anti the medical professionals, but it’s time the guidelines were updated. 

Here's a link to a BBC news article on this subject.

Trigger warning: it deals with suicide.

https://www.bbc.co.uk/news/uk-scotland-66430817

I believe the data referred to cases where cannabis had been mentioned specifically on a death certificate. Alcohol is a lot more dangerous, and had it been recently discovered, ethyl alcohol would probably be a controlled drug! The fact that it has been in use for thousands of years means it has become socially acceptable.

"Cannabis psychosis" is interesting. Many years ago I did a very basic psychopharmacology course at a university summer school, and the evidence was that there was a correlation, which of course is not evidence of causation. As in most things, I suspect that as we find out more about genetics we will find that some people have genetic factors which affect various receptors, and the neurotransmitters are unbalanced in some way. It may be that in time, as genetic sequencing becomes more available, we will see research into "personalised" medication, including psychopharmaceuticals.

Having ADHD, I slept about three hours a night as a kid. I was taking promethazine for my asthma, in doses that should have at least made me drowsy - it didn't. You may know that it was the sedative side-effect of the antihistamine promethazine that led to the formulation of chlorpromazine for use as a tranquiliser. Nor do I get a "buzz" from caffeine - I used to consume huge amounts of coffee - twenty cups a day, each with two heaped teaspoonfuls of instant coffee. That was probably 50% over the maximum daily dose listed in BNF. It helped me sleep!  (In the USA I tried Jolt Cola. I had two cans and two double espressos, which is getting on for 400mg of caffeine stat. I went back to my hotel room and fell asleep.) As a trainer, I ask the audience " So why do we give hyperactive kids speed? Ritalin is a stimulant."  It is one of the few paediatric drugs where body mass does not affect the dose. You can have a tiny five-year-old on 20mg and a large teenager who only needs 5mg.[Discussed in Hallowell and Ratey,1994  " Driven to Distraction"]

There was some research published recently regarding coffee. Apparently, subjects were given either coffee with a known caffeine content, or the same amount of pure caffeine in hot water. [https://scitechdaily.com/brewing-clarity-the-unique-neurological-effects-of-coffee-over-plain-caffeine/]

This was the point I was making about herbal cannabis vs synthetic THC or CBD. "The few studies done with CBD in serotonergic systems suggest that it inhibits 5-HT re-uptake, and overall reduces 5-HT neurotransmission (2,16). There is also some experimental evidence to support CBD’s activity in other neurotransmitter systems such as dopamine,GABA, and the endogenous opioid system." [Russo et al 2015 Agonistic Properties of Cannabidiol at 5-HT1a Receptors.]  Of course, CBD is available in soft drinks available over the counter in any supermarket.  Maybe what we need is a proper clinical trial of some of the individual components of herbal cannabis.

I state that it is not medical advice; they are not. I can tell you to ask a specialized doctor. § They are old generation drugs, we go back to 1969 as the date of discovery if I remember correctly. Marketed in 1985. With an idea of selectivity. So the idea was very good.There is an opposite category of SSREs, enanchers and these are SSRIs inhibitors. The first was unsuccessful, then the second yes, the third is very famous, then there are really many others. The doctor explained to me the effects that each drug actually has, he was unable to tell me how they work, but that they are selective ::It is assumed that they work in one way on male NT individuals,On NT women she said they hadn't been tested then, yes now, and some seem to work very well.Autistic : we are different , so it is writing you about something different in different and in your exceptionality of a different person. A rebus within the rebus, paraphrasing Sir Winston Churchill (he was answering a question about the USSR at the time9::§Citalopram, it doesn't mean anything that you hired him, it must always be established by the specialized person the modality, the quantity, the timing as Tris wrote if I am not mistaken. § There is one with a different formulation even if similar, escitalopram. § Attention because as many have said here, our extreme sensitivity counts for autistics, and following the dosages, keep in touch with the doctor especially in the initial phase, who evaluates. §They weren't useful in my case. But one must never say they wouldn't be for anyone: it wouldn't be correct. if you have the leaflet underline your doubts and ask him

§Nobody or hardly anyone does it and then they ask us for advice as we are not doctors. §If they work as they rightly wrote, they need weeks at a valid dosage. §Usually doctors do good for their patients. Usually we are so different .I was very bad, but it's my case and that's it.My case and that's it: initial gastric bleeding.(In my case, I stress it carefully):§I stress that this is NOT medical advice from which I distance myself, but only my experience §There is precision medicine, doctors are clear that they can understand the right drug or not in a very short time, without trying. A medical exam is enough, which you will obtain only on request, and is non-invasive. A blood marker test. § From there you can avoid any problems by following an established procedure, this is at least in our national health system. §You don't go by chance and you don't go by trial and error, but by specific medical tests. in which the doctors will be able to establish with certainty which works or not. §A) Medical advice b) Asking doctors for very simple blood tests that have been around for a long time.c) Never interrupting a drug can have serious consequences D) Believe only in doctors: trust me) the therapy must be associated with a psychological therapy adapted to the autism spectrum, therefore specific and not generalistf) Absolutely never use do-it-yourself drugs of any kind, nor use what you have at home, without a clear medical requestg) Evaluating an exact diagnosis for an autistic is not easy, therefore contact those who understand us, because we are not like NTf) do not look at the Internet: there are too many fakes and they lead people in an evident state of confusion into very serious errors. g) from ex student, I write to you that many problems are really similar to each other only a medical diagnosis solves these, and some are also for us as identical .h)Like any drug in the world there are side effects and potentially useful effects.This is evidenti)Who he uses drugs he must be respected: he has courage, he takes care, and he is certainly not an ***. He has a lot of courage. § I will end with the fact that I am not at all responsive to any drug, I am worse off, and they have certified it several times. I am not responsive to psychological therapies: I don't understand them. But I would like to write to you that they are from effective meta-analytic studies, some obviously cannot be studied on a large scale, and for that reason they do not have meta-analytic studies because they are also not homogeneous. § If you are not sure you have done the right choice, ask another specialist.§Ask for a differential diagnosis.§Never abandon therapy on the advice of strangers, and others on the web.§Always: be careful because it is best not to be left alone in the first phase.§I hope to not have violated any rule. In case you have my consent to the immediate elimination of the written post. §
Thanks

"Cannabis related" deaths. What does that mean exactly? 

And 20 out of how many million regular users? How does that compare to the recommended social use drug alcohol in terms of safety? Or for that matter the recent vaccinations? Or even the drugs that have taken away my friends power of speech having been clearly over prescribed by a whole TEAM of professionals?

If a thing happens to you, and you are a regular cannabis user, then of course it is "involved" or "related". 

The oft touted link between cannabis and schizophrenia or psychosis is definitely real but is cannabis the cause or a self-selected treatment? 

And why, after decades of active suppression, is my side of the argument clearly winning the "war" with legalisation (if only by the back door as with cancard) being rolled out everywhere if the stuff is so dangerous or toxic? 

I'm personally sorry to find myself so in opposition with you tonight Ian, in some of your previous posts you've revealed yourself as quite well motivated and well balanced in your thinking, but in this area and some others I do feel your message requires a bit of argument or as I see it, counterpoint.

From my own perspective although I've found the stuff overall helpful I've also found it very, "challenging" on occasion, and unlike most cannabis advocates was carful to conceal my own use from my child though her most impressionable years and am glad she does not feel the need to use it regularly. 

But in my own case, although I sometimes resent having to pay for it, or go and buy more when I run out, and I sure resent being somehow considered morally deficient for using it regularly, I have proven over several decades of careful and occasionally not so careful testing, that it confers overall a steadying effect on my psyche which allows me to function better and more safely in society than when I do not take the stuff.

When I've tried more conventional alternative treatments they've been disastrous, and NOT beneficial to my functioning. 

"Yer pays yer money, yer takes yer choice".  If you are allowed (or allow yourself) to have a choice, of course... 

Statistics on https://www.statista.com/topics/6200/medical-cannabis-in-the-uk/#topicOverview are that there are approximately 20 deaths p.a.. However, I would imagine that there are many more cases where cannabis use has contributed to deaths by accident and suicide, or where cannabis has exacerbated underlying psychosis. There are about 80 deaths caused by driving under the influence of drugs, and cannabis was the most common cause of impairment after alcohol.

" Cannabis is involved in approximately 50% of psychosis, schizophrenia, and schizophreniform psychosis cases. Cannabis is a known risk factor for schizophrenia, although the exact neurobiological process through which the effects on psychosis occur is not well understood."  (Shivastrava, Johnson et al, 2014Indian J Psychiatry. 2014 Jan-Mar; 56(1): 8–16.doi: 10.4103/0019-5545.124708 ) 

Whilst there is evidence that cannabis can be effective in depression (it appears to act on both serotonin and dopamine) the trouble is that herbal cannabis contains dozens of psychoactive substances in different proportions. I would be wary of messing about with the balance of one's neurotransmitters.

It goes without saying that possession of a controlled drug without a prescription is illegal.

Those patient information sheets list every  "side effect" that is ever reported using a Yellow Card (or the online system that replaces them). They can be useful for warning about drug interactions, foods to avoid (grapefruit and grapefruit juice have a lot of interactions) etc., but they can be quite tedious to read.

That's true. It's sometimes used to counteract SSRI overdoses.

Periactin 2mg before bed

It's now six minutes past eight and I've just finished screaming "NO, NO, NO, THIS IS WHY I DON'T COOK!!" 

-as my second attempt at heating up a slice of pie ends in disaster... OH well, it was short lived, but I was genuinely happy there for a short while...

FWIW, It's quarter to seven in the morning, I've been up about an hour and a half, fed the cats had a tea and smoked a small number, and I've processed all the overnight information emails etc, that I want without interruption, and my cats have joined me. 

One is curled up next to me warming my leg and purring softly and the other one content on the floor next to me, as I type this.

Eventually I'll get up, make another tea, and breakfast on Morello Cherry pie from Waitrose, (which a little bird told me is actually made by Wrights Pies, and which I was last able to buy (as a "Wrights cherry pie" in 2014)*. 

I've been just as effing miserable (for vast tracts of time) as any of you, have (obviously) tried most drugs in an effort to escape, but right now, just the warm feeling on my leg from Blackie's head (he is of course A big Ginger cat, everyone tells me off for naming him that, but I have my reasons, mainly being the pythonesque humour) and I know THIS is what I needed all those years... 

.... And now a decent section of pie is in the oven, cat's have had a second helping of food, Blackie's gone out for his morning constitutional I've got my tea and I'm just deciding what I'll attempt today. Looks like a nice day, so I think I'l cut mine and my neighbours lawns, followed by trying to progress this motorcycle refurbishment a bit.

*This cherry pie is "something special", and for any misguided souls who ever doubt my veracity, and quality of advice, the proof is in the eating... :c)

RTFM!

Since my first run in with the medication suicidal thoughts fairy I tend to read them every time I'm prescribed something new. If you don't know about the side effects or possible interactions with other drugs/food/drink etc., then how are you supposed to know what you should and shouldn't do or be worried about?

I know not everyone responds well to them but I've found going on Sertraline life changing - but in a good way! Before I went on antidepressants/anti anxiety meds I couldn't go out, I couldn't attend medical appointments and I was frightened all the time and felt lower than I've ever felt before. 

All that's changed now. I still get anxious and I still get bad days where the low train comes in to station but it's a lot less and a lot more bearable for me than it used to be.

I'm sorry you've been suffering this way mate. I hope this passes for you soon or you can get some different meds that will work better for you.

I really like the phrase drug family! It's made me think about what family members my drugs would be, like my antidepressants/anti-anxiety meds would be siblings, the antihistamines would be the great aunt you only see at certain times of the year, and the anti-tremor medication for my RLS would be the mum that puts you to bed in the evenings. In a grown adult so that last one is a bit weird but it fits.

I will just add to this that I am on Seroxat (Paroxetine) now and it keeps me calm and is a very valuable member of my drug family.

But you can separate and identify the active compounds that give the beneficial reaction. That's exactly what all drugs are and how they're developed. Note, no-one is eating mouldy bread for the penicillin, we're taking the antibiotics derived from it through extensive experiments and testing.

The medication my husband takes for his heart condition is derived from digitalis but again, he's not eating foxgloves.

We're thankfully at a point with our science where we can identify the helpful bits and refine them in such a way that any negative side effects can be reduced and the active compounds can be administered more effectively.

They're doing the same with psilocybin, there's multiple trials going on looking into its effectiveness in treating depression, and so far results are looking promising.

And just to clarify, I have tried both weed and mushrooms in my past, so I'm not talking from an inexperienced point here. Neither benefited me in the long run and frankly the thought of doing either whilst I'm in a major depressive or anxious episode is incredibly off-putting.

As you've said, you are talking about your own experience, so I've talked about mine.

My family would not be here without the advances in medical science.

My husband has a congenital heart defect that as little as 50/60 years ago would have been an infant death sentence but they can now correct that in utero, and he has a pacemaker that originally was suitcase sized and pulled around by the person but is now implanted in his chest and can send updates to his cardiologist wirelessly.

His brother has type 1 diabetes, synthetic insulin keeps him alive and he has a handy little pump that monitors his levels and automatically regulates how much insulin is given.

My son was born at 32 weeks, his survival chances without the medical care and support of the Special Care unit at the hospital would have been 50/50 at best.

There's a solid reason I advocate for medical solutions to health problems, the science has to be thoroughly assessed, tested and is constantly evolving.