Hypersensitive patches of skin

My partner gets patches of skin that are ridiculously sensitive and complains his skin is raw and his clothes are rubbing. He will actually get a red sore patch on his skin from it. I thought it was the clothes causing it but since the same t-shirt can cause it one day but not the next it is confusing. He says that the areas feel like there are hundreds of little needles stabing his skin 

Barr bodies can also occur in males that have more than one X chromosome, e.g.,XXY (Klinefelter syndrome). If this might be a possibility to why you have hypersensitive *patches* of skin, it might be possible to discuss with your GP for further consultation. 

I'm not sure if this is the case of what you are describing as it's hard to tell just through a few sentences of description online, and I'm not a qualified doctor to make any diagnoses, but in case you would like to read more, here's a wikipedia link (though unfortunately it doesn't give the sweat gland example):
https://en.wikipedia.org/wiki/X-inactivation 

btw, here's a picture of a calico cat who has patches of different colours.

Are you female by any chance? I was wondering if this might have something to do with the Barr body? (in females one of the X chromosomes is the inactive in the somatic cell). In a classic genetics book example, this can be seen in calico cats and tortoiseshell cats. Humans females that are heterozygous for the X-linked disorder anhidrotic ectodermal dysplasia have mosaics of skin cells carrying the normal allele linked to the inactive X chromosome giving rise to patches of skin with no sweat glands, together with regions of cells carrying the normal allele linked to the active X, giving rise to patches of skin with normal sweat glands.

http://www231.pair.com/fzwester/courses/bis10v/week6/mosaic.gif

I have a tiny spot on my back that causes my spine to arch reflexively if it's touched... never gave any thought that it might be linked to ASD...

I have a patch of skin on my left forearm that is allergic to sunlight...

The patches aren't necessarily big - perhaps the size of a hand.