Autism pathogenesis: Piecing it all together, from end to beginning ...

What’s your angle? 

Trying to find the cause? Trying to eliminate the condition coming about? Just curious...

Yes.

My son was diagnosed with multiple life-threatening food allergies and asthma at ~1 year old.

At ~5, he received four vaccine shots in one sitting, developed anaphylaxis, spent the night in the ICU. Now these vaccines are contraindicated and he has no protection from these vaccine preventable diseases.

Our doctors did not know what caused it nor did they have a cure. I had no option but to research the matter myself (what would you have done in my position?). I am an electronics engineer with no formal training in medicine or immunology.

In engineering, finding a good solution involves determining root cause by understanding the mechanism of failure.

It became quickly obvious that food protein contaminated vaccines cause the food allergy epidemic.

I published my findings.

Evidence that Food Proteins in Vaccines Cause the Development of Food Allergies and Its Implications for Vaccine Policy

https://zenodo.org/record/1034553

While investigating the above, I found that most cases of autism are simply a special case of cow's milk allergy.

NAS50294 said:

While investigating the above, I found that most cases of autism are simply a special case of cow's milk allergy.

Have you considered perhaps that most cases in those particular studies; involve cow's milk allergies as being a result of Autism, possibly?

Folate deficiency during brain development can cause irreversible damage. There is no compensation for it.

NAS50294 said:

Yes, I am aware of the alternative route, but you cannot reverse ALL the damage.

It is not so much about reversing all the damage, but giving the body means by which to compensate for it.

"He explained that when IgG4 as you state blocks folate uptake, that alternative routes are achieved quite readily,"

Yes, I am aware of the alternative route, but you cannot reverse ALL the damage. Prevention is therefore better than cure.

Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial

www.nature.com/.../

NAS50294 said:

Thanks for the links.

Glad to be of some assistance.

NAS50294 said:

Stress, high cortisol are general insults.

Very much so, especially as in my case the insult involves  psychogenic seizures, or Psychological Non Epileptic Seizures. The reason for which being given medication to save my life that just about but not quite obviously did the opposite, when I was three.

I very much appreciate that you have not had a receptive welcome, and very much understand the problems your family has been going through ~ yet the insults you decry is an insult , and such an approach literally needs to be discontinued. 

This information is being provided for the good of your son, in good faith. I mean no harm and hope that you like everybody else lives long and prospers session! :-)

NAS50294 said:

Even if they caused allergy, one would expect allergy to a wide variety of items.

With a compromised immune system, it is like a car with minimal fuel and thus minimal range of travel. There are also different genetic origins to take into consideration, and the ecology of each individual's particular environment, in or from whichever continent.

Basically though people who live in the country and come into contact with bacteria more in general have robust immunities, and people have flimsy ones in cities where cleanliness or over-cleanliness is more generally the rule.

NAS50294 said:

Why are they specifically developing allergy to bovine FRA?

Nutraceutical, a term combining the words "nutrition" and "pharmaceuticals", is a food or food product that provides health benefits as an adjuvant or alternative therapy, including the treatment and prevention of infectious diseases in children and adults. There is emerging evidence that bovine colostrum (BC) may be one of the promising nutraceuticals which can prevent or mitigate various diseases in newborns and adults. Immunity-related disorders are one of the leading causes of mortality in the world. BC is rich in immunity, growth and antimicrobial factors, which promote tissue growth and the maturation of digestive tract and immune function in neonatal animals and humans. The immunoglobulins and lactoferrin present in colostrum are known to build natural immunity in newborns which helps to reduce the mortality rate in this population. Also, the side-effect profile of colostrum proteins and possible lactose intolerance is relatively less in comparison with milk. In general, BC is considered safe and well tolerated. Since colostrum has several important nutritional constituents, well-designed, double-blind, placebo-controlled studies with colostrum products should be conducted to widen its therapeutic use. The objectives of this review are to create awareness about the nutraceutical properties of colostrum and to discuss the various ongoing alternative treatments of colostrum and its active ingredients as well as to address colostrum's future nutraceutical and therapeutic implications in humans.

https://www.researchgate.net/publication/273699739_Bovine_colostrum_An_emerging_nutraceutical

This was suggested by my friend/colleague which he said you should research in line with your son's condition as diagnosed.

He said given the nature of what you report, you will probably need to get the bovine colostrum during the six hour period after the calf has been born, as after the twelve to twenty four hour stage it starts becoming the production of milk. Organic really is best on this one.

Another suggestion is the following on Leaky Gut Syndrome and Autism:

https://www.sciencedaily.com/search/?keyword=leakey+gut+syndrome+and+autism#gsc.tab=0&gsc.q=leakey%20gut%20syndrome%20and%20autism&gsc.page=1

My friend / colleague for whom immunological disorders are his his specialised field of research, said that leaky gut syndrome can be resolved relatively simply with chicken bone broth ~ refer to link:

https://ihm.life/heal-leaky-gut-with-bone-broth/

Another factor perhaps worth considering also is Thrush / Candida:

https://www.healthline.com/nutrition/candida-symptoms-treatment#section4

In respect of the paper, my friend / colleague said that you did not to have the necessary degrees to understand or comprehend the complexity or errors involved with your suggestions. He explained that when IgG4 as you state blocks folate uptake, that alternative routes are achieved quite readily, which he did go through regarding a series of examples in quick and casual 'shop-talk' succession, but due to my dyslexia thing and not as being my field of research, I was unable to follow, write legibly or now report.

One thing he was very clear about though, is that you need to focus on the 'particularities' of son's 'individual' condition instead.

And get your son diagnosed with Autistic Spectrum Disorder before even imagining to advise other parents on the matter!

Also recall or consider anew the statement "Publish and be damned" ~ as can involve legal action for presenting unqualified health advice. A detrimentally affected individual, or the corporation who produced the vaccine your son was given ~ would not have to make you look legally accountable regarding your paper in its own right. It's a "Cruiser to a bruiser" he said.

If you feel though that you must do something, consider more the area of particulate pollution as it has major loaded traction in the scientific community as being a definitive causality:

https://www.sciencedaily.com/search/?keyword=Autism+and+pollution#gsc.tab=0&gsc.q=Autism%20and%20pollution&gsc.page=1

Along with which now also the major concern regarding the rising environmental pollution and the increasing health problems worldwide that must be resolved by the end of the next decade.

In order not to unsettle anybody too much I have found again a paper that was written at the begging of this century (2003), a very very good one methinks, which is more introductory to the problem of particulate pollution, and thus less challenging as a happening right now sixth mass extinction event read.

https://academic.oup.com/bmb/article/68/1/1/421204

Oh ~ I spoke to another friend / colleague who said that he wished people would offer an alternative when complaining about things. The thing is the pharmoclogical industry has lost the battle against super-viruses, what with increases in viruses and bacteria in general that are being defrosted from what was once considered the permafrost, and those developing anew at a massive rate too as things warm up. So in truth you are protesting against something that is really on it's final years as the all important big deal, with the only remaining option being Phages:

NAS50294 said:

Thanks for the links.

Glad to be of some assistance.

NAS50294 said:

Stress, high cortisol are general insults.

Very much so, especially as in my case the insult involves  psychogenic seizures, or Psychological Non Epileptic Seizures. The reason for which being given medication to save my life that just about but not quite obviously did the opposite, when I was three.

I very much appreciate that you have not had a receptive welcome, and very much understand the problems your family has been going through ~ yet the insults you decry is an insult , and such an approach literally needs to be discontinued. 

This information is being provided for the good of your son, in good faith. I mean no harm and hope that you like everybody else lives long and prospers session! :-)

NAS50294 said:

Even if they caused allergy, one would expect allergy to a wide variety of items.

With a compromised immune system, it is like a car with minimal fuel and thus minimal range of travel. There are also different genetic origins to take into consideration, and the ecology of each individual's particular environment, in or from whichever continent.

Basically though people who live in the country and come into contact with bacteria more in general have robust immunities, and people have flimsy ones in cities where cleanliness or over-cleanliness is more generally the rule.

NAS50294 said:

Why are they specifically developing allergy to bovine FRA?

Nutraceutical, a term combining the words "nutrition" and "pharmaceuticals", is a food or food product that provides health benefits as an adjuvant or alternative therapy, including the treatment and prevention of infectious diseases in children and adults. There is emerging evidence that bovine colostrum (BC) may be one of the promising nutraceuticals which can prevent or mitigate various diseases in newborns and adults. Immunity-related disorders are one of the leading causes of mortality in the world. BC is rich in immunity, growth and antimicrobial factors, which promote tissue growth and the maturation of digestive tract and immune function in neonatal animals and humans. The immunoglobulins and lactoferrin present in colostrum are known to build natural immunity in newborns which helps to reduce the mortality rate in this population. Also, the side-effect profile of colostrum proteins and possible lactose intolerance is relatively less in comparison with milk. In general, BC is considered safe and well tolerated. Since colostrum has several important nutritional constituents, well-designed, double-blind, placebo-controlled studies with colostrum products should be conducted to widen its therapeutic use. The objectives of this review are to create awareness about the nutraceutical properties of colostrum and to discuss the various ongoing alternative treatments of colostrum and its active ingredients as well as to address colostrum's future nutraceutical and therapeutic implications in humans.

https://www.researchgate.net/publication/273699739_Bovine_colostrum_An_emerging_nutraceutical

This was suggested by my friend/colleague which he said you should research in line with your son's condition as diagnosed.

He said given the nature of what you report, you will probably need to get the bovine colostrum during the six hour period after the calf has been born, as after the twelve to twenty four hour stage it starts becoming the production of milk. Organic really is best on this one.

Another suggestion is the following on Leaky Gut Syndrome and Autism:

https://www.sciencedaily.com/search/?keyword=leakey+gut+syndrome+and+autism#gsc.tab=0&gsc.q=leakey%20gut%20syndrome%20and%20autism&gsc.page=1

My friend / colleague for whom immunological disorders are his his specialised field of research, said that leaky gut syndrome can be resolved relatively simply with chicken bone broth ~ refer to link:

https://ihm.life/heal-leaky-gut-with-bone-broth/

Another factor perhaps worth considering also is Thrush / Candida:

https://www.healthline.com/nutrition/candida-symptoms-treatment#section4

In respect of the paper, my friend / colleague said that you did not to have the necessary degrees to understand or comprehend the complexity or errors involved with your suggestions. He explained that when IgG4 as you state blocks folate uptake, that alternative routes are achieved quite readily, which he did go through regarding a series of examples in quick and casual 'shop-talk' succession, but due to my dyslexia thing and not as being my field of research, I was unable to follow, write legibly or now report.

One thing he was very clear about though, is that you need to focus on the 'particularities' of son's 'individual' condition instead.

And get your son diagnosed with Autistic Spectrum Disorder before even imagining to advise other parents on the matter!

Also recall or consider anew the statement "Publish and be damned" ~ as can involve legal action for presenting unqualified health advice. A detrimentally affected individual, or the corporation who produced the vaccine your son was given ~ would not have to make you look legally accountable regarding your paper in its own right. It's a "Cruiser to a bruiser" he said.

If you feel though that you must do something, consider more the area of particulate pollution as it has major loaded traction in the scientific community as being a definitive causality:

https://www.sciencedaily.com/search/?keyword=Autism+and+pollution#gsc.tab=0&gsc.q=Autism%20and%20pollution&gsc.page=1

Along with which now also the major concern regarding the rising environmental pollution and the increasing health problems worldwide that must be resolved by the end of the next decade.

In order not to unsettle anybody too much I have found again a paper that was written at the begging of this century (2003), a very very good one methinks, which is more introductory to the problem of particulate pollution, and thus less challenging as a happening right now sixth mass extinction event read.

https://academic.oup.com/bmb/article/68/1/1/421204

Oh ~ I spoke to another friend / colleague who said that he wished people would offer an alternative when complaining about things. The thing is the pharmoclogical industry has lost the battle against super-viruses, what with increases in viruses and bacteria in general that are being defrosted from what was once considered the permafrost, and those developing anew at a massive rate too as things warm up. So in truth you are protesting against something that is really on it's final years as the all important big deal, with the only remaining option being Phages:

Folate deficiency during brain development can cause irreversible damage. There is no compensation for it.

NAS50294 said:

Yes, I am aware of the alternative route, but you cannot reverse ALL the damage.

It is not so much about reversing all the damage, but giving the body means by which to compensate for it.

"He explained that when IgG4 as you state blocks folate uptake, that alternative routes are achieved quite readily,"

Yes, I am aware of the alternative route, but you cannot reverse ALL the damage. Prevention is therefore better than cure.

Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial

www.nature.com/.../