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Research into pre-natal causes of autism

scienceobservation

Hi. I'm a mum of three. We don't have autism in our family, but my third son showed many of the signs at aged 3: poor eye contact, lack of vocal recognition, biting, slow to learn and write. Luckily, with loving parents and teachers he developed wonderfully and made a loving group of friends. I have always been interested in autism as a mum in the community and have friends with children who have autism. I am also interested in scientific observation and thought - but definitely not speculation or unscientific causation. I understand autism is a neurodevelopmental disorder to do with brain systems and is spectral in range. I think that research should be directed to prenatal influences in the uterus - interesting research might be: raised CRP levels in mother are a sign that the body is undergoing response to inflammation due to virus/bacteria and increase CRP = autism in babies; Fifth disease B19 Paravovirus in mothers linked with prenatal fetal anaemia causing intercerebal hemorrhage. I also find interesting the link that austic children also have a higher prevalance of leaky gut syndrome and this is also connected to B19 virus and gut microbiota. There is also a link between PLEVA virus and B19 in older children, with PLEVA being more prevalant in boys. In summary, these are merely observations and things I have read up on in respected scientific jounals and papers as an interested mum with an active brain! Could our increasingly sterile modern environment coupled with the skewed increase in prescription of antibiotics have alters gut microbiota and decreased our resistance to B19 causing a rise in prenatal infection and brain damage shown in the rise in cases of autism worldwide? The brain-skin-gut connection has been thrown into the spotlight recently, particularly in relation to depression and mental health. I hope scientists can pull in funding to research properly these links thoroughly because somewhere in this lies the answer to the causes of autism. If we can develop a vaccine to protect mums-to-be against B19 and understand better prenatal brain damage which causes the brain to enlarge, then we could be on the right track.

Parents
  • Former Member
    Former Member

    Hi Laddie,

    There are a number of points in your post that highlight how difficult it is to separate nature, nurture and the impact of external factors like environmental chemicals.

    I would guess that your mother had some sort of personality issues that lead her to be obsessive, addictive and poor at being a mother. Autistic genes are likely to be a factor and she may have had a harsh childhood herself. It is very difficult to work out which came first, in these situations, and I suspect that your problems have been compounded by her limited abaility to be a loving mother. You have to trace it back further though and analyse what her parents were like and why they were like that. There is little point attributing blame in any of this, we (and they) are all victims of circumstance.

    You describe yourself as having an addictive personality. Is that different to the obsessive and narrow focus that is a feature of a lot of autistic peoples lives? A lot of us have obsessions. These are often used to provide evidence of the disorder during the diagnostic process. I suspect that some issues with alcohol and nicotine may be more related to the stress that a lot of autistic people find themsleves in. Again, it is hard to work out what is a response to a situation and what is an inborn personality trait.

    In all of this, I try to understand all of the issues and, when I have enough explanations and understanding, I find it much harder to be judgemental about people's role in my downfall. Better to accept that I am what I am and move on and make the most of it.

Reply
  • Former Member
    Former Member

    Hi Laddie,

    There are a number of points in your post that highlight how difficult it is to separate nature, nurture and the impact of external factors like environmental chemicals.

    I would guess that your mother had some sort of personality issues that lead her to be obsessive, addictive and poor at being a mother. Autistic genes are likely to be a factor and she may have had a harsh childhood herself. It is very difficult to work out which came first, in these situations, and I suspect that your problems have been compounded by her limited abaility to be a loving mother. You have to trace it back further though and analyse what her parents were like and why they were like that. There is little point attributing blame in any of this, we (and they) are all victims of circumstance.

    You describe yourself as having an addictive personality. Is that different to the obsessive and narrow focus that is a feature of a lot of autistic peoples lives? A lot of us have obsessions. These are often used to provide evidence of the disorder during the diagnostic process. I suspect that some issues with alcohol and nicotine may be more related to the stress that a lot of autistic people find themsleves in. Again, it is hard to work out what is a response to a situation and what is an inborn personality trait.

    In all of this, I try to understand all of the issues and, when I have enough explanations and understanding, I find it much harder to be judgemental about people's role in my downfall. Better to accept that I am what I am and move on and make the most of it.

Children
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