Anyone self medicate on psychedelics ?

I'm a bit sceptical of genetic studies like the one you cite. HTTLPR polymorphism was trumpeted as implicated in depression until they found out they couldn't replicate the results.

Still, psychedelics are something that you will see continually get scientific attention because of their profound effect (various mentions in New Scientist), and indeed drug companies have tried making money from one enantiomer of ketamine. There's also increasing interest in the Psychedelic Society.

For me, I've had only negative reactions to SSRIs and other antidepressants. But I do find beneficial effects of alcohol and caffeine in moderation and have in the distant past tried other things in moderation. LSD creates a 'fluidity' or openness that I know other people found to be the only effective thing for their OCD. While alcohol makes you (feel) less autistic, LSD probably increases sensory sensitivity, but also maybe overcomes a 'tramline' rationality and enables access to (positive) emotions and things that are otherwise inaccessible.  As you probably know, LSD used to be used as an adjunct to psychotherapy. 'Set and setting' are important supposedly with both psilocybin and LSD, so comfortable environment with friends would seem to minimise any chance of a bad trip (of which I hear more on psilocybin than LSD).

As I see it there are two main barriers to LSD being available on prescription or more widely for research purposes: (a) it's only effective in tiny and occasional doses, so hard to reasonably make money from. Esketamine was approved in the USA, but not UK, probably taking into account a price of about £400 a dose; (b) it's not patented, so again hard to make money from (it is chiral, so maybe there could be an enantiomer patented.) If those two were sorted, public political perception might change as it often does under drug company influence.

There are a few other threads here mentioning psychedelics: here here here 
And quite a lot of stuff on Youtube academic on MDMA; personal about LSD; live experience

I'm a bit sceptical of genetic studies like the one you cite. HTTLPR polymorphism was trumpeted as implicated in depression until they found out they couldn't replicate the results.

Still, psychedelics are something that you will see continually get scientific attention because of their profound effect (various mentions in New Scientist), and indeed drug companies have tried making money from one enantiomer of ketamine. There's also increasing interest in the Psychedelic Society.

For me, I've had only negative reactions to SSRIs and other antidepressants. But I do find beneficial effects of alcohol and caffeine in moderation and have in the distant past tried other things in moderation. LSD creates a 'fluidity' or openness that I know other people found to be the only effective thing for their OCD. While alcohol makes you (feel) less autistic, LSD probably increases sensory sensitivity, but also maybe overcomes a 'tramline' rationality and enables access to (positive) emotions and things that are otherwise inaccessible.  As you probably know, LSD used to be used as an adjunct to psychotherapy. 'Set and setting' are important supposedly with both psilocybin and LSD, so comfortable environment with friends would seem to minimise any chance of a bad trip (of which I hear more on psilocybin than LSD).

As I see it there are two main barriers to LSD being available on prescription or more widely for research purposes: (a) it's only effective in tiny and occasional doses, so hard to reasonably make money from. Esketamine was approved in the USA, but not UK, probably taking into account a price of about £400 a dose; (b) it's not patented, so again hard to make money from (it is chiral, so maybe there could be an enantiomer patented.) If those two were sorted, public political perception might change as it often does under drug company influence.

There are a few other threads here mentioning psychedelics: here here here 
And quite a lot of stuff on Youtube academic on MDMA; personal about LSD; live experience