Anyone self medicate on psychedelics ?

Not advocate anything, but Im wondering if any one experiments with things to improve their mental health.

These things are safe if your educated, I just have a theory on Polymorphism on the serotonin receptors and transporters.
Sorry if it all sounds too complicated, I'm interested in your experiences as I'm trying to base an idea on this paper.
http://europepmc.org/article/PMC/2739682