My daughter hates her brother

Like any other siblings, they don't always get along but this issue is having a very negative on my 7 year old son. Both my daughters are horrid to him. My eldest is the worst. She will be throwing knives at him, things across the room, swear at him and is always negative towards him. She would sometimes lash out and kick and hit him. My other daughter, 13, would get involved and shout at him and snatch things from him but that's as far as it goes with her. 

My son is now very anxious, still wetting the bed from anxiety, and copies behavior. He is throwing, swearing and will stand and scream sometimes and will lash out. He will hurt the dog which really upsets and frustrates the girls. I have also caught him with a lighter setting paper on fire in his bedroom. I don't know where he got it because we don't smoke or use lighters at all. 

He is very anxious and struggles to sleep and then wakes up early so he's tired. He calls himself an idiot all the time because that's what my daughters call him. He also thinks no one loves him and said he would rather die. I have tried years to solve these issues and help them get along but it is no use and things are getting worse. My eldest is diagnosed with autism and I know she struggles socially and doesn't engage much with us, which we are working on. She also is sensitive to noise so is usually shouting at him because his music is too loud, or he is being too noisy. I agree that he is extremely loud. There is no quiet I him. I just don't know what to do.