Polygenic and developmental profiles of autism differ by age at diagnosis ?

Reading through the report it seems the essence is that they believe 2 different genetic aspects are present for autists (for the purpose of this study) and that people with one aspect are most likely to present as autistic when in early childhood while the other group are likely to present much later, sometimes only in adulthood when pressures cause the autistic traits to become more pronounced.

Males showed a higher genetic corrolation for autism than females.

Concerns for me are that the childhood detection is a bit of a lottery from what I have read on this forum. Some schools have good SENCOs and some don't which can lead to later diagnoses based on which school they attend.

Hopefully this will improve with time so long as the government don't cut the budgets ( a bit of a big ask at the moment).

I note that they did not find any sort of corresponding age related presentation profle for ADHD people which is odd.

They do admit that the older diagnosed sample may be "contaminated" by misdiagnosed patients:
The higher genetic correlation between later-diagnosed autism and other mental-health conditions may indicate diagnostic misclassification (in which individuals with other conditions incorrectly receive an autism diagnosis) or diagnostic overshadowing (where the presence of co-occurring mental-health conditions can delay an autism diagnosis)

The research seem solid with a good sample size and they admit that they don't know what the real genetic links for autism are but the fact they can take a genetic profile and identify pobable autists can be a good and a bad thing.

Good because it gives parents advance warning to understand it, learn how to cope with it and hopefully to setup a proper care pipeline through education to allow the child to reach their best potential.

Bad because it gives a big neon sign over the babies head that they will probably be a net burdon on society and have a lower chance of being economically non-contributory in their adult life ( I'm basing this on the fact only 22% of autistic adults are in any kind of employment - NAS statistics).

The government under leadership like Trump and RFK Jr can then have the option to send them to "special care facilities" should they choose. A bit of a distopial extrapolation of things but I believe this is withing their potential to do.

It is a bit like the pre-crime division in Minority Report - they can now spot potential autists and remove them before they become a "problem".

However, this is all conjecture. The report is good research and has some interesting results.

Reading through the report it seems the essence is that they believe 2 different genetic aspects are present for autists (for the purpose of this study) and that people with one aspect are most likely to present as autistic when in early childhood while the other group are likely to present much later, sometimes only in adulthood when pressures cause the autistic traits to become more pronounced.

Males showed a higher genetic corrolation for autism than females.

Concerns for me are that the childhood detection is a bit of a lottery from what I have read on this forum. Some schools have good SENCOs and some don't which can lead to later diagnoses based on which school they attend.

Hopefully this will improve with time so long as the government don't cut the budgets ( a bit of a big ask at the moment).

I note that they did not find any sort of corresponding age related presentation profle for ADHD people which is odd.

They do admit that the older diagnosed sample may be "contaminated" by misdiagnosed patients:
The higher genetic correlation between later-diagnosed autism and other mental-health conditions may indicate diagnostic misclassification (in which individuals with other conditions incorrectly receive an autism diagnosis) or diagnostic overshadowing (where the presence of co-occurring mental-health conditions can delay an autism diagnosis)

The research seem solid with a good sample size and they admit that they don't know what the real genetic links for autism are but the fact they can take a genetic profile and identify pobable autists can be a good and a bad thing.

Good because it gives parents advance warning to understand it, learn how to cope with it and hopefully to setup a proper care pipeline through education to allow the child to reach their best potential.

Bad because it gives a big neon sign over the babies head that they will probably be a net burdon on society and have a lower chance of being economically non-contributory in their adult life ( I'm basing this on the fact only 22% of autistic adults are in any kind of employment - NAS statistics).

The government under leadership like Trump and RFK Jr can then have the option to send them to "special care facilities" should they choose. A bit of a distopial extrapolation of things but I believe this is withing their potential to do.

It is a bit like the pre-crime division in Minority Report - they can now spot potential autists and remove them before they become a "problem".

However, this is all conjecture. The report is good research and has some interesting results.