Not paracetamol - Neanderthal?!?! (Don't tell the US president)

My social media feed just alerted me to this study from 2024 https://www.nature.com/articles/s41380-024-02593-7

According to this, it's not that autistic people have more Neanderthal DNA than neurotypicals just that unique brain related DNA found in Neanderthals is more common in autistic people.

The study reckons this explains and correlates with differences in social cognition and visual processing in autistic people as carry overs from the neurodiversity of early humans.

The study, as so many do, says that "more research is necessary".

So what do we think?

Another example of 2 plus 2 making 42 from eager scientists?

OK, if the evidence is good maybe that helps explain what's occurring and maybe where things come from?

And, possibly, so what??

I'm off to light the camp fire for dinner... meanwhile, thoughts anyone?

:-)

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  • This is fascinating, yet I would be highly suspicious of reaching conclusions due to the limited availability of clinical data, especially as it’s in the US. The study makes this limitation abundantly clear, so I agree that “more research is necessary”.

    I would be interested to understand more about this point:

    Hybridization in non-human species is recognized as a destabilizing event with the potential to promote compensatory adaptation in other regions of the genome and, ultimately, speciation in some lineages [40]. Therefore, there is an additional possibility that Homo sapiens specific variants that evolved after Neanderthal introgression may nevertheless be in influenced by these earlier events.

    Separately from this study, there is an ongoing argument around classifying non-Homo Sapiens as humans, e.g., should we call Neanderthals humans or are they a different species. So is the study alluding to Neanderthals not being human? If yes, that may have negative connotations if it is being linked to autism. I prefer to think of Neanderthals being human, especially since it is suggested that we contain DNA from multiple types of yet to be identified ancestor.

    My DNA has been analysed and in common with most people of European heritage, I have around 2% Neanderthal DNA. Some of this means I am likely to be a better sprinter than long distance runner— correct— well, it was at one time! 

    Can I join you at the camp fire? 

  • I share your suspicion   of research limitations and also when there is an element of "fashionability" in this case combining two scientific hot topics.

    Nonetheless it is interesting isn't it! (also with Jane Goodall recently passing there's a thread that joins the pattern maybe).

    I remember learning on one of the silly number of podcasts that I consume that roughly 60% of the Neanderthal genome is shared out in living hominids - yes I agree that hominid means "human" and maybe in some cases "great apes" - I subscribe to Neanderthals as being humans too :-)

    The camp fire is always free for other humans (or should I say trusted animals?) to sit around :-) along with sharing food, water and stories that's a basic given (hehe unless really out of sorts when it's best to tell to go in the cave and do some paintings or clear off and gather some wood for the fire!)  

  • If our descendants in thousands of years from now were to see some of my ‘cave art’, they might suggest that Sapiens were unsophisticated and unintelligent. I suspect that would not be said of the gorilla or chimp! Fire woman shruggingorangutanGorillaWink

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