Autism pathogenesis: Piecing it all together, from end to beginning ...

Arumugham V, Trushin M V. Autism pathogenesis: Piecing it all together,
from end to beginning ... . J Pharm Sci Res. 2018;10(11):2787

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  • Only one vaccine in the UK contains bovine products, Repevax.

    Repevax is not given to pregnant women, nor children until the age of 3 years 4 months: Repevax is not the only vaccine used at this age, Infanrix IPV is also used. The Summary of Product Characteristics sheets (SPC) for Infanrix IPV does not list bovine products. 

    You are conflating the known positive effects of certain diets on children that present challenging behaviour and severe symptoms, with the causes of autism. You are mistaking a correlation for a cause.

    I have suggested to parents asking for advice on this forum about challenging behaviour that they try a casein free diet, omega 3 and or probiotics. The last research I saw on this posited that up to 30% of children may benefit. Strategies to alleviate symptoms do not point to a cause.

    To suggest that dirty vaccines are responsible for 70% of autism diagnoses flies in the face of the mountains of research on vaccines. To suggest that bovine products are the cause when they are not present in any vaccines until over the age 3 years 4 months is disingenuous. Particularly in light of all the research during the BSE fiasco.

    Immunoglobulins do not cross the blood/brain barrier, in fact penetrating this barrier is one of the holy grails of the pharmaceutical industry.

    There has been much debate about the genetic - environmental trauma causes of autism, including on this forum. Recent improvements in the preservation and working practices involved in the clinical studies of postmortem brains, have shed further light on the molecular abnormalities in ASD via transcriptomic analyses. Further research in this area will bring us closer to understanding the molecular pathways to synaptic development, RNA editing etc.

    Using a sample of 4,408,646 subjects, autism has been demonstrated to have a heritability rate of 64%. This matches with a number of research projects: this one that ascertains that gene expression is atypical at 5 to 22 weeks post conception: Heritability likelihood has been used to test machine learning algorithms on the fMRI scans of 6 month old children with high familial risk for ASD.

    One common occurence in the brains of those with autism is the initial overproduction of neurons and the subsequent atypical pruning of neurons. Many of the genetic markers found are involved in this process. Not just neurons but synapses and astroglial activation. My theory is that this process results in the extremely wide spectrum called autism, from savant to severe psychological difficulties. This paper on the amygdala - the fight or flight  area- is the latest to demonstrate this process.