Among 13 included studies, there was a statistically significant association between neonatal jaundice and ASD
Using guidelines of the Meta-analysis of Observational Studies in Epidemiology Group, we systematically reviewed the literature on neonatal jaundice (unconjugated hyperbilirubinemia) and Autism Spectrum Disorder (ASD) in term and preterm infants.
Thirteen studies were included in a meta-analysis. Most used retrospective matched case–control designs. There was significant heterogeneity (Q = 31, p = 0.002) and no evidence of publication bias (p = 0.12). Overall, jaundice, assessed by total serum bilirubin (TSB), was associated with ASD (OR, 1.43, 95% CI 1.22–1.67, random effect model).
This association was not found in preterms (OR 0.7, 95% CI 0.38–1.02) but deserves further investigation since other measures of bilirubin such as unbound unconjugated bilirubin may be better predictors of neurotoxicity than TSB in preterms.
Two things I found interesting. Jaundice is an indication of brain trauma (neurotoxicity). And this is seen more in term babies than in preterm. Does the size of the baby matter? Does going full term have an increased risk for ASD.
Also, do we actually know when a baby is a full term or not. As women's cycles vary shouldn't gestation?
My son had a period of jaudice after his was born (he's 15 now and quite a different colour). Full term in my "gestation" but via caesarean section as he was breach and couldn't be arsed to turn around ....
Not sure about myself as don't have family really to talk to about it....Maybe as I'm the only yellow jelly baby in the packet so got ostrasized
" Jaundice in babies
Jaundice is common in newborn babies because babies have a high number of red blood cells in their blood, which are broken down and replaced frequently.
A newborn baby's liver isn't fully developed, so it's less effective at processing the bilirubin and removing it from the blood.
This means the level of bilirubin in babies can be about twice as high as in adults.
By the time a baby is around 2 weeks old, they're producing less bilirubin and their liver is more effective at removing it from the body.
This means the jaundice often corrects itself by this point without causing any harm."
Full term is counted as after 37 weeks. I haven't read this study but there have been several tenuously linking premature (36 weeks or earlier) and low birth weight with asd. 3 out of 4 of my children were premature and little 4lb 8oz and under only one is showing any signs of asd. The youngest was earliest smallest and had jaundice but so far not displaying any traits but he is only 18 months!
My son was 36 weeks (due to booking the C-section) and weighed 8lb 7 oz - pretty healthy weight. My son is not diagnosed as being on the spectrum btw.
Yeah, 8lb 7oz is good for 36 weeks! My daughter was also at 36 weeks she was 4lb 8oz and awaiting assessment my youngest was 35 weeks and 4lb 6oz so far we are sure he is nt.
sure. what is also important is what is left out of the NHS description. "Bilirubin is a yellow substance that's made when the body breaks down old red blood cells, improperly"
What causes old red blood cells in newborn babies?
Premature babies red blood cells break down faster
No one is suggesting everyone's baby with jaundice has ASD. The number of cases of jaundice was higher in people with ASD than without. A lot of research points to trauma at birth as the cause of autism. Trauma either from birth complications or infection. And some are saying that the drip causes autism.
My thought is that we are continually told what is normal, healthy, expected, etc. And sometimes nature has its own answer.
Glad you have a lovely baby boy, and is now a bit darker.
Anything on the trauma of life causing ASD? Maybe it can make certain behaviours more pronounced?
Lagrangian said: A lot of research points to trauma at birth as the cause of autism. Trauma either from birth complications or infection. And some are saying that the drip causes autism.
My son is now 15 as is as delightful as any teenager can be :)
A few of those things were listed as possible factors when my daughter was referred. Birth trauma, premature, low birth weight, induced using drip then she got group b strep infection causing sepsis and pneumonia as well as clots on her brain, add to that they blew her lung so she couldn't be ventilated properly meaning her blood gasses were toxic. All were listed as reasons that she would be likely to have "complications" personally I think it is more genetic we are sure my partner is also asd
My daughter had to be resuscitated. She was drowsy from the pain meds. I think they waited a bit too long to see if she was breathing. she took her to a rescus thing with a lamp. I followed the nurse and she then they gave her air.
Now at 9 no asd/adhd diagnosis though. I will be pressing for this from school. the mum isn't interested. And thought our daughter wasn't dyslexic. Now the school thinks the remedial work has cured her "a little problem with spelling"
I sent my dyslexia report and am waiting to hear back about asking for an ECHP. Sadly I need both school and mum on side to help our daughter and son. Both jaundiced.